Vitamin A, TRAIL and Cancer

Vitamin A or retinol plays many critical roles in the body. Unfortunately, most of the people in the world are deficient in dietary vitamin A intake.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=10521699&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12230799&itool=pubmed_docsum

Retinoic acid, a derivative of retinol, is well known to induce death in cancer and leukemia cells. A few years ago, a study found that retinoic acid induced the synthesis of TRAIL in certain leukemia cells.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=11385504&itool=pubmed_docsum

TRAIL is an immune hormone which activates JNK and induces apoptosis in virtually all cancers and leukemias. Unlike TNF and FAS ligand, other natural JNK activators, TRAIL is completely non-toxic to normal cells. Many TRAIL based clinical trials are presently in operation.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17485341&itool=pubmed_docsum

In our cytotoxic treatment protocol, we are trying to kill cancer and leukemia cells by apoptosis, a non-inflammatory death pathway. The activation of TRAIL synthesis by retinoic acid is something we definitely want to promote.

Interestingly, NF-kappaB inhibits the apoptosis inducing properties of TRAIL. We have ways of dealing with NF-kappaB activation so this shouldn't be a problem.

In the treatment protocol, I recommended a dose of 25,000IU of vitamin A daily. This is a minimum dose. If you have an advanced cancer, take 100,000IU of vitamin A, or 4 doses of 25,000IU per day.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

Comments

[Shin]

At 100,000IU of vit A per day, is there an issue of harm to the liver at this dose ?

[Dr. Steve]

There is no harm in the short term. RA has been used in doses of 1 million IU for the treatment of certain leukemias.

See the next blog essay.

[Magdalena]

Hi Steven,

Due to the fact that I had not enough 95% curcumin I took curcumine with Ginko Biloba (10%)which I had still at home. I have the feeling that this increases the bonepain much more than curcumine alone.

I found the following on Pubmed:

1: Biol Pharm Bull. 2005 Dec;28(12):2181-4. Links
Ginkgetin, a Biflavone from Ginko biloba leaves, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells.Son JK, Son MJ, Lee E, Moon TC, Son KH, Kim CH, Kim HP, Kang SS, Chang HW.
College of Pharmacy, Yeungnam University, Gyongsan 712-749, Korea.

Ginkgetin, a biflavone from Ginkgo biloba leaves, was previously reported to be a phospholipase A(2) inhibitor and this compound showed the potent antiarthritic activity in rat adjuvant-induced arthritis as well as analgesic activity. This investigation was carried out to find effects on cyclooxygenase-2 (COX-2) in vitro effect. Ginkgetin inhibits COX-2 dependent phases of prostaglandin D(2) (PGD(2)) generation in bone marrow-derived mast cells (BMMC) in a concentration-dependent manner with IC(50) values of 0.75 microM. Western blotting probed with specific anti-COX-2 antibodies showed that the decrease in quantity of the PGD(2) product was accompanied by a decrease in the COX-2 protein level. In addition, this compound consistently inhibited the production of leukotriene C(4) (LTC(4)) in a dose dependent manner, with an IC(50) value of 0.33 microM. These results demonstrate that ginkgetin has a dual cyclooxygenase-2/5-lipoxygenase inhibitory activity. Furthermore, this compound also inhibited degranulation reaction in a dose dependent manner, with an IC(50) value of 6.52 microM. Therefore, this compound might provide a basis for novel anti-inflammatory agents.

Could this be from any interest for the protocol.

Hopefully I will receive my curcumine tomorrow. I can further experiment with these curcumines, if this would be interesting.

[Dr. Steve]

Fine, do some experiments. But we are not recommending that you take curcumin alone. Parthenolide from feverfew will enhance its activity and bone pain as well.

[Magdalena]

I am doing the whole protocol as suggested including the feverfew. But due to the fact that I did not have the curcumine powder yet (but still had some capsules with 95% curcumine and capsules with curcumine with 10 % Ginko Biloba which I took, I noticed the difference)

Further, could it be possible that the discussiongrouppe is open to anyone, thus non-describers too? I have opened it on another computer, without using a username.

[Dr. Steve]

No it not open. Tell me what you did and I will tell the webmaster.

[Magdalena]

I just went to the homepage of Kurosawa and opened the discussion grouppe. Opened again ie.
http://grouppekurosawa.com/discussion

and I was in the grouppe.

[Dr. Steve]

The top three or four titles in the administration part are open to the public. Did you see all the forums on cancer, etc.

They are not supposed to be open to the public.

[Magdalena]

Indeed, I saw all the forum, including the new protocol.

Also on my own computer: If I open the natural B-log I need to type in my username, However, for the discussion grouppe, somewere described below (not one of the four upper subjects) this is NOT necessary. I am directly ,after double klick on http://grouppekurosawa.com/discussion middle, in the discussion grouppe and I can give responses or open a new topic.

That's why I asked my questions over here.

[Magdalena]

The problem with the discussion grouppe is solved. Ik was continuously logged in. The login botton could not be standard seen on the screen.

Once I received a prescription of farmaceutical quality Retinol parmitate 30.000UI (JENAPHARM).
I can ask my familydoctor do give me such description. My question is: is this better than the vit.A (beta-caroteen/retinolparmitate) offered on the internet?

[Dr. Steve]

Don't make this complicated. Just take common vitamin A.