Sulindac is a Strong Stat3 Inhibitor.

Sulindac is an inexpensive generic prescription drug used in the treatment of inflammatory diseases. Although sulindac is a Cox-1 and Cox-2 inhibitors, its anti-cancer properties VASTLY exceeds its ability to directly inhibit the activity of Cox enzymes.

Sulindac was originally included in our cytotoxic treatment protocol. I dropped it because it was a prescription drug. Recent scientific studies suggest that this was a BIG mistake.

Sulindac inhibits the activity of Cox enzymes and prostaglandin PGE2 synthesis while activating the alternative, pro-apoptosis NF-kappaB signaling pathway. There is now evidence that sulindac is also an inactivator of STAT3 signaling. Sulindac inhibits the activation of STAT3 while simultaneously promoting the degradation of the STAT3 protein.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=11861373&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17401459&itool=pubmed_docsum

Keep in mind that STAT3 is extremely immunosuppressive while activating a host of pro-survival factors, including VEGF and survivin. You can conduct a search on this blog for the relevant essays.

Sulindac's ability to inhibit survivin synthesis is directly linked to its ability to block STAT3 activity.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17566705&itool=pubmed_docsum

Again, keep in mind that survivin the principle inhibitor of the TRAIL death pathway signaling.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16820920&itool=pubmed_docsum

Sulindac is being returned to the cytotoxic treatment protocol. It is a prescription drug but it is not difficult to obtain. Acetaminophen, Tylenol, will now be considered an option in both the cytotoxic and immune protocols.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

Comments

[satx2]

I don't have a primary care/GP and my urologist doesn't want to help me "manage" my prostate cancer (he recommends only prostatectomy), so I have no one to "ask your doctor" about a sulindac or dutasteride prescription.

Anybody have any suggestions where I could score a prescription? I'm not familiar with the complex scam job call US health care.

[craig]

Google "Buy Sulindac". There are lots of companies that sell it without a prescription.

[Thea Hardy]

So would we be taking the sulindac in conjunction with the SS, and also with acetaminophen? Do they work better together? I suspect I can get my local doc to prescribe sulindac without difficulty - she knows the inflammation is a problem.

Am anxious to get the methyl jasmonate and start on that.

Thanks, as always, for the work, Steve, and also to all the rest of you for the sense for community!

[Dr. Steve Martin]

SS and sulindac is the BIG TWO right now. Acetaminophen only inhibits Cox-2 so it is not as important as the previous two. Nevertheless, it remains an option. Cox-2 has to be inhibited one way or the other.

[SteveK]

If Sulindac inhibits Cox 1/2 and Stat3 why is the SS needed?

[Dr. Steve Martin]

Because they are synergistic. SS does more than sulindac, at least according to the literature. We NEVER depend on one compound for therapeutic purposes.

[satx2]

I'm putting in orders for stuff for a new treatment phase for prostate cancer, to see if in the next 3 months I can knock down my PSA from 5.0.

SS and meltonin I have.

Sulindac, MJ I can get.

Do I use all four?

What about the other protocol stuff I'm taking?

Ascorbyl palmitate plus 5000 IU Vit D3 in 1/8 cup of coconut oil?

Vit A?

Acetaphenomin?

Niacinimide?

Sodium selenite?

You've got and already said sanguinaria is OK.

[satx2]

Every "buy sulindac" hit I've found has been "requires prescription".

I could go to walk-in clinic for $90 and take 1 minute to ask for a prescription to buy a $35 product, but could get refused. 1 minute, $90, no prescription. I don't want to pay to play and then lose.

[satx2]

OK, as usual. After posting above, I went back and kept trying. Next hit worked, Sulindac apparently "in the mail".

And a pound of triphala from Kalyx.

[Dr. Steve Martin]

Where did you buy the sulindac on the Net.

[Craig]

I ordered 20 tabs of Sulindac at http://mexmeds.com.mx for $12.

We will see if it arrives.

[Ed]

Craig,
Have you received the Sulindac you ordered from Mexmeds? If not, would you let us know if and when you do? Thanks.

Ed

[Craig]

I have not yet received the medications I ordered. I did however get a charge on my card, which was totally unauthorized for $522.27 from a website called dfs-shopping.com. It seems that someone has stolen my credit card information...
What a bunch of bs...

[Dr. Steve Martin]

OK, no more purchases in Mexico. Protest the charge with the credit card provider now. I had a $195 unauthorized charge three weeks ago. I filed a fraud report with Wells Fargo bank and those bastards backed up immediately. They refunded my money.

[Paul Kobulnicky]

I ordered mine on the 19th and received it yesterday. They still haven't taken it out of my account. Anyway, for the heartburn, would cimetidine be as good or better than Prilosec?

[Dr. Steve Martin]

NO. Only Prilosec or Pepacid.