Grouppe Kurosawa Natural Medicine Blog Archives

The Medical Administration of the Anti-Cancer Plant Hormone Methyl Jasmonate

Through the efforts of Grouppe Kurosawa, methyl jasmonate is now being used by many people throughout the world to treat their cancers. Physicians in many countries are administering this plant hormone to their patients and keeping records of their clinical progress.

MJ is an oil like substrance. The most effective method of introduction into the body is via the lungs. The lungs contain the highest concentration of blood vessels of any organ for obvious reasons.

MJ is introduced into a small personal steamer such as that manufactured by Vicks. The steamer is filled with distilled water, the MJ is floated on the top of the water, the heat is turned on and people breathe the MJ into their lungs via the steamer mask. Although some minimal irritation has been reported, this can be minimized by breathing through the mouth and nose. AT THE VERY LEAST, we feel that MJ is the ONLY hope for the treatment of lung and brain cancers. Lung cancer is the most common cancer in the world.

MJ CANNOT be introduced into the lungs with a nebulizer. Nebulizers, such as those used in the treatment of asthma, are designed to introduce specifically formulated compounds into the lungs. Nebulizers ARE NOT designed to volatilize oils such as MJ. The MJ will clog up the nebulizer and ruin it. The steam is necessary to get the MJ into the lungs and the blood stream.

Although MJ can be dissolved in 70% DMSO gels for topical applications, this is meant for specific applications. This method of entry cannot possibly duplicate the efficacy of direct entry of MJ into the lungs.

Skin Alive is a registered trademark of our skin cream. This cream has amazing medicinal properties, including desensitizing skin to topical allergies, such as nickel, and it includes methyl jasmonate. MJ is a direct inhibitor of the enzyme 5-lipoxygenase, a pro-inflammatory enzyme involved in many skin conditions and diseases. Skin Alive (R) is not available commercially because we do not have the money to manufacture and promote the product on a large scale. Skin Alive (R) is not a treatment for cancer.

I hope this essay answers some of your questions.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

Sodium Selenite Reactivates Silent Anti-tumor Genes in Prostate Cancer

When we think of genetic factors which predispose people to developing cancer, we usually think of mutations in selective growth control genes. These mutations are irreversible. But what most people do not realize is that there is another group of genetic alterations which influence the development of cancer that are not mutations and ARE reversible. These genetic factors are considered epigenetic modifications of gene functioning.

Many genes, especially tumor suppressor genes, are inactivated when certain DNA sequences in these genes are hypermethylated. Gene methylation is a normal method by which gene activity is modulated. Unfortunately, DNA methyltransferases, the enzymes which transfer the methyl group to the gene sequences, are over expressed in almost all cancers. Prostate cancer harbors a very large number of methylated, therefore inactive, genes.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=15657340&itool=pubmed_docsum

The reactivation of these genes by DNA methyltransferase inhibitors is a major area of scientific research.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17998812&itool=pubmed_docsum

The oncogene RAS, which exists in mutated form in 30-50% of ALL cancers and leukemias, is responsible for the over activation of the DNA methyltransferase genes, thereby stimulating the production of a large number of gene silencing methyltransferase enzymes. Those cancers that do not harbor mutations in the RAS gene have mutations in downstream RAS signaling pathways that also can contribute to DNA methyltransferase activity.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=7744770&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=7829490&itool=pubmed_docsum

When DNA methyltransferase genes are introduced into normal cells, these cells become transformed or cancerous. If DNA methyltransferase genes are "turned off" by chemical means, the DNA in these cancer cells becomes demethylated and the cells die of apoptosis. DNA methyltransferase enzymes are clearly fundamental for the cancer transformation process.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=7713905&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=8415627&itool=pubmed_docsum

A number of DNA methyltransferase inhibitors are in development. Unfortunately, some of these inhibitors have proven toxic to normal cells. Sodium selenite is a powerful inhibitor of DNA methyltransferases. The selenite molecule directly binds the methyltransferase enzyme and inhibits its activity. This inhibition has NOTHING to do with selenite's ability to induce oxidative stress. This means that selenite can induce apoptosis in cancer and leukemia cells regardless of their p53 status. This is very good news.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18676679&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=9600343&itool=pubmed_docsum

Sodium selenite remains a critical component of our cancer and leukemia treatment protocols. The dose is one milligram per day, or five 200 microgram pills over the course of a day. This dose of selenite is not toxic in humans.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

Sodium Selenite is an Anti-Cancer Agent Especially for Prostate Cancer

Sodium selenite is a component of our general cancer treatment protocol. We use sodium selenite because it rapidly depletes glutathione from cancer cells. This leads to oxidative stress and cancer cell death.

http://grouppekurosawa.typepad.com/grouppe_kurosawa_natural_/2008/03/sodium-selenite.htm

The mitochondrial oxidative stress induced by sodium selenite can be inhibited by the mitochondrial enzyme MnSOD, manganese superoxide dismutase.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18379781&itool=pubmed_docsum

Interestingly, the synthesis of MnSOD can be inhibited by the active form of vitamin D.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17604335&itool=pubmed_docsum

Since we are all relatively deficient in vitamin D, it makes sense that sodium selenite supplements would be impaired in their ability to induce oxidative stress in the absence of this vitamin.

There is another problem. Selenite induced oxidative stress and cancer cell death is dependent on the expression of the tumor suppressor p53. This is the major tumor suppressor in the body.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16489034&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16891474&itool=pubmed_docsum

Unfortunately, 50% of all cancers harbor mutations in the p53 gene, thereby minimizing the ability of oxidative stress to induce apoptosis in cancer cells.

Selenite is also known to block the activation of the gene for the testosterone receptor. It accomplishes this task by inducing oxidative stress. Oxygen radicals, in turn, inhibit the activity of the genetic factor Sp1 which is responsible for the activation of the testosterone receptor gene. Again, in the absence of p53 activity this is not going to happen.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16928829&itool=pubmed_docsum

Selenite's ability to kill cancer and leukemia cells transcend its ability to reduce glutathione and induce oxidative stress. In the next essay, I will present some exciting evidence that selenite directly inhibits the methylation of DNA gene sequences and the modification of histones which inhibits the activation of important genes, such as those producing tumor suppressor factors. Selenite reactivates these dormant genes. Prostate cancer is known to have an over abundance of methylated genes.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

                                                                                                                                                                  

The Economy Hits Grouppe Kurosawa

Rumors of my death have been exaggerated. I haven't posted anything for some time because I have been preoccupied with making a living. I no longer have an income as a scientific consultant to law firms. That income stream dried up when the economy went bad. Presently I am trying to get more publicity for my little book on home made topical remedies for pain, hair loss and herpes infections. Since I have to carefully watch my savings, I no longer purchase scientific articles. The average scientific article costs $30.

The good news is that I am now shipping methyl jasmonate all over the world. The Israeli scientists who wrote the bulk of the culture dish MJ studies know about GK and our MJ studies. They are not happy about it. They have told people who contacted them that MJ has not been properly tested in humans and that the inhalation of MJ is probably illegal. What a crock! These are the same people who said that MJ is in the same chemical toxicity category as table salt. They have a patent on the use of MJ to treat cancer, but it is completely unenforceable. No Pharma company is going to touch MJ. It is not a patentable molecule and it could wipe out the cancer drug market. If GK does not test this molecules effectiveness with its volunteers, it is never going to happen.

I will be posting new essays in the next few days.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com