Methyl Jasmonate Directly Inhibits the Enzyme Necessary for Prostate Cancer Growth and Survival

Recently, CNN produced a great segment on the poor diet of Americans. They cited American Heart Association studies which showed that Americans consume 10% of their calories from soybean oil. If you look on a package of almost anything in a store, it contains hydrogenated soy oil. This is an omega six oil which is extremely unhealthy. The high linoleic fatty acids present in soy, corn, and safflower oils is converted to arachidonic acid in the body. Arachidonic acid is the precursor to prostaglandins and leukotrienes.

We already know that the prostaglandin PGE2 is immunosuppressive in addition to stimulating the growth and survival of cancer cells. But this is only part of the story. The enzyme 5-lipoxygenase produces a leukotriene called 5-HETE which has been linked to cancer growth of all kinds. In a culture dish, 5-HETE will stimulate the growth of cancer cells all by itself.

Many cancers over express the 5-lipoxygenase enzyme, including prostate, bladder, breast and lung cancers. Prostate cancer is known to substantially over express this enzyme. When the activity of this enzyme is inhibited, the cells die of apoptosis.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=11241241&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=9199209&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=11511519&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=12460891&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16903934&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17552358&itool=pubmed_docsum

The last article is quite interesting because it shows that the simultaneous inhibition of both Cox-2 and 5-lipoxygenase synergistically kills lung cancer cells. This makes perfect sense.

The following study is one of my favorites. It shows that the specific inhibition of 5-lipoxygenase in both hormone-dependent and independent prostate cancer cells die of a MASSIVE apoptosis within hours. Specific inhibitors of Cox-2 and other enzymes do not induce a comparable apoptosis response. Since 5-HETE, a product of the 5-lipoxygenase enzyme, is a growth factor for prostate cancer cells, this data makes perfect sense.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=9789062&itool=pubmed_docsum

Methyl jasmonate binds directly to the 5-lipoxygenase enzyme and inhibits its activity. The main anti-cancer properties of methyl jasmonate concern its ability to damage the mitochondria of cancer but not normal cells. Now a new dimension of MJ's ability to kill cancer cells has been linked to the direct inhibition of 5-lipoxygenase activity.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18038760&itool=pubmed_docsum

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

Comments

[void]

Curcumin also inhibits COX-2 and 5-LOX.

http://cat.inist.fr/?aModele=afficheN&cpsidt=16078087

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WPH-4C8MTT6-6&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=26714550e8c5c0c18499b87bf048494e

Could curcumin act synergistically with methyl jasmonate at this point?

[Dr. Steve]

It might, but curcumin is only effective in high blood concentrations. We cannot attain these concentrations with oraol usage.

[jbehles]

For anyone interested, 5-lipoxygenase is also overexpressed in colon cancers and polyps as well.

http://clincancerres.aacrjournals.org/cgi/content/abstract/14/20/6525

[Gerry]

I wonder how MJ compares with 5-Loxin from Boswellia in its 5-lipoxygenase inhibition powers.

[Toni Reid]

Hi...this is from Toni Reid who has a white count of 56,900...we spoke a week ago Sunday...I am now needing your contact so I can purchase methyl Jasmonate....did all on PayPal...just need your info...please send to toni.reid87@gmail.com ...many thanks...Toni Reid