Sodium Selenite Blocks HIV Latency and Promotes Cell Mediated Immunity

HAART, highly active antiretroviral therapy, is the current gold standard for the treatment of HIV infections. Unfortunately, these drugs are very expensive and somewhat toxic, especially to normal liver functioning. HAART drugs can reduce the level of HIV virus in the blood to very low levels, but they cannot "sterilize" the body of the HIV virus. Very early in all HIV infections, a state of viral latency is established in many immune cells. Latency means that the virus has infected various cells, but these cells do not produce virus. HAART cannot kill latently infected immune cells. The virus DNA, integrated into the DNA of the cells, remains inactive. This might seem like a good idea, but it is clearly not. If HAART therapy is terminated, many of these latent cells begin producing virus. As such, HAART therapy must be taken forever if an HIV "virus rebound" is to be prevented. This is unacceptable. HAART drugs are out of the price range of the poor. Secondarily, the body eventually develops a resistance to the efficacy of these drugs over time.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17845138&itool=pubmed_docsum

In reading "between the lines" of some scientific studies, we have developed a better treatment protocol for HIV infections.

The HIV gene is inactivated, i.e. it remains latent, if certain gene sequences become over methylated. DNA methylation is caused by the enzyme DNA methyltransferase.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=8496786&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=2323336&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=3469417&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=8496786&itool=pubmed_docsum

The immune hormone TNF, a pro-inflammatory hormone that promotes HIV synthesis, activates latent HIV infections by inducing a demethylation of the HIV gene.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17034647&itool=pubmed_docsum

HIV viral proteins, early in infection, induce the synthesis of DNA methyltransferase enzymes resulting in the methylation of a wide variety of genes. One of these genes is the HIV gene itself, resulting in a state of viral latency. In addition, the gene for gamma interferon, a major activator of cell mediated immunity, is also methylated. This results in the inactivation of the gamma interferon gene and an impairment of a cell mediated immune response against virally infected cells.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=9710601&itool=pubmed_docsum

Since the over methylation of genes, specifically those of tumor suppressors, is a major factor in the development of cancer, a great deal of research has been conducted on the development of synthetic DNA methyltransferase inhibitors. The following study shows that sodium selenite, a common supplement, is a specific inhibitor of DNA methyltransferase activity.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18676679&itool=pubmed_docsum

The dose is one milligram of sodium selenite a day, 5x 200 micrograms doses spread over 24 hours or so. Sodium selenite is the ONLY form of selenium that is acceptable.

When combined with HAART therapy, sodium selenite should be able to reactivate HIV latently infected cells. In addition, it promotes cell mediated immunity via the activation of the gamma interferon gene. Sodium selenite can also be used without HAART therapy as an inexpensive stand alone treatment for HIV infections. Only time, and volunteers, will be able to report the efficacy of sodium selenite as a treatment for HIV infections.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

Comments

[GS]

This will help a lot of good people out there Dr. Martin please keep up your wonderful work :) wouldnt it be wonderful to get 1mg of selenite distributed in 2 time released pills taken BD. Do you have any info on what antioxidants will and which ones wont mediate this effect since selenite is oxidative(too oxidative for us). I read somehwere resveratrol also deactivates latency. I can almost sniff a new protocol coming. Ok the reason why GS is latent these days is my moms getting 14 artesunate injections IV combined with glutamine. 2 more shots and we ll get some tests. Will keep the blog posted. My fingers are crossed and i tremble with anxiety. I really need luck now.

[GS]

Here is the study i talked about. HIV requires some of the same functions that are implicated in the development of cancer including MAPK signalling.
Resveratrol an Anticancer agent and antioxidant activates Egr1, a gene whose product causes cell growth to slow, creating favourable conditions for HIV replication...actually pushing the virus out of latency.Ok..it works but sounds contradicting... The study is here.
aidsmap.com/en/news/6B6DC32A-B85E-4461-8592-6075406EA72C.asp

Here is another study which states - Dramatic increase in immune mediated HIV killing activity induced by Echinacea angustifolia.
gateway.nlm.nih.gov/MeetingAbstracts/ma?f=102229824.html
Incidentally Echinacea also contains compounds similar to caffeine which brought me back to Dr. Martins Blog essay : Caffeine Inhibits Synthesis of the HIV Virus in T Lymphocytes by 94%
However caffiene is or isnt an immune stimulant... remains to be seen. If there are any HIV mice out there - please help our sensei finish the task at hand :)Selenite - Resveratrol - Echinacea might just be the answers to millions of prayers. Dr. Martin is Good at intercepting prayers and answering them :)

[Dr. Steve]

What are these injections for?

[Larry Bowen]

GS,
My question too, how did you decide to do the artesunate which is prescribed as a last line of defense against malaria? I realize that there are some people who maintain that artemisinin is cytotoxic with certain cancer cells but also know that research and real results on this are real sketchy. Would be interested in how you arrived at your decision to start your mom on this protocol.
All the best,
Larry B.

[jbehles]

I have seen some stuff about artesunate on the web...it seems to me that anti-malarial drugs are cytotoxic to cancer cells, for example, oleander extracts and chloroquine. I wonder why that is?

Here is an article on chloroquine:

http://www.medicinenet.com/script/main/art.asp?articlekey=86060

[GS]

These injections are for the mets lymph on the peritonium. I wrote to 2 of the Scientists who are doing the research on artemisinin derivateives. One of them wrote back the same day and told me artesunate works well over IV. He also wrote about how to give it and where to buy, whom to call. I took an appointment with my moms oncosurgeon as i was concerned about damaging the portal vein. He asked us to first get a, CA15-3 & liver function test first and if we found anything wrong with the LFT, this test was to be followed by a HIDA scan and subsequently an endoscopic stent if required. The HIDA and the stent werent required.. and he gave us the Green signal for artesunate and MJ. The man is a compassionate and highly sought after onco surgeon in india. Works on multiple patients simultaneously with several assistants.
He also helped us get the prescription so that we could take the first shot in the hospital for monitoring, We paid noting for the prescription. I have to report back with the results to both docs the day after. Our Surgeon thinks we still have time to take action and avastin combined with another pill will suffice. The ca15-3 was 44. I believe this can go into hundreds and even thousands when the cancers get agressive. I think the entire credit of controlling this cancer with an iron fist goes to Gods Grace and then Dr. Martin. I cant Thank you enough Dr. Steve :) I still hold that i was sent to your site because of some prayer God answered.

[GS]

Incedentally the Doc who didnt write back uses Artemix (mixture of the three ARTE forms)I got this info from a company that wanted to sell me herbal artemisinin. Dr. Martin had warned me a long long time back that the herbal wormwood was useless here.

[GS]

Good News! The Marker Ca15-3 is down from 44 to 35 in 15 days flat. Will follow with an ultrasound image on monday :)

[GS]

Ultrasound Report! The lymph didnt budge in Size... The Oncologists have asked for a FISH test to check for HER2 Status. Will keep you guys posted. BTW.. meanwhile the Doctor wants to continue with ArT.. he felt the drop in CA15.3 was appreciated.

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